Chimeramycins. New macrolide antibiotics produced by hybrid biosynthesis.

Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.

Sir: Microbial conversion of antibiotically inactive macrocyclic lactones to active compounds is an important approach in the search for new macrolide antibiotics. Mutational biosynthesis originally proposed by SHIER et al.1) was proved useful also for constructing new macrolide antibiotics and many new derivatives were obtained. However, these were virtually inactive,2-1) or weakly active and ...

New macrolide antibiotics produced by mutants from Streptomyces fradiae NRRL 2702.

New antibiotics miyakamides produced by a fungus.

New antibiotics, miyakamides A1, A2, B1, and B2, were isolated from the cultured broth of Aspergillus flavus Link var. columnaris FKI-0739 together with known compounds, parasiticolide A, hydroxyaspergillic acid, and kojic acid. The structure of miyakamide A1 is N-acetyl-L-phenylalanyl-N-methyl-L-phenylalanyl-(alphaZ)-alpha,beta-didehydrotryptamine, and miyakamide A2 is E isomer of A1 at didehy...

A new Micromonospora-produced macrolide antibiotic, rosamicin.

A new antibiotic, rosamicin, classified as a macrolide, has been isolated from the fermentation broth of a new species of Micromonospora, M. rosaria. The antibiotic is separated from the broth by a solvent extraction procedure and purified by column chromatography. Chromatographic studies indicate that rosamicin is different from all related macrolides and is a novel antibiotic. It has broad-sp...

Antibiotics produced by Streptomyces.

Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a chain of spores. The most interesting property of Streptomyces is the ability to produce bioactive secondary metabolites, such as antifungals, a...